Acute kidney injury aki in patients with cirrhosis is common mehta rl bouchard j controversies in acute kidney injury effects of fluid overload on outcome contributions to nephrology 2011 174200 211 10 gines p angeli p lenz k et al easl clinical practice guidelines on the management of ascites spontaneous bacterial . Molitoris ba sandoval rm 2011 kidney endothelial dysfunction ischemia localized infections and sepsis in j kellum j l vincent c ronco eds controversies in acute kidney injury contributions to nephrology vol 174 pp 108 118. The acute loss of kidney function has been diagnosed for many decades using the serum concentration of creatinine a muscle metabolite that is an insensitive and non specific marker of kidney . Acute kidney injury aki is a common complication impacting short and long term patient outcomes although the application of the classification systems for aki has improved diagnosis early clinical recognition of aki is still challenging as increments in serum creatinine may be late and low urine output is not always present. Acute kidney injury aki is a serious and as yet incompletely understood disorder in which sudden impairment of kidney function occurs secondary to one or more of a variety of underlying conditions
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